Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase.

Dihydroorotate dehydrogenase (DHOD) is a pyrimidine biosynthetic enzyme which is usually directly linked to the mitochondrial respiratory chain. Antimalarial naphthoquinones such as atovaquone (566c80) inhibit malarial DHOD by inhibiting electron transport. Since atovaquone also has therapeutic acti...

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Εκδόθηκε σε:	Antimicrob Agents Chemother
Κύριοι συγγραφείς:	Ittarat, I, Asawamahasakda, W, Bartlett, M S, Smith, J W, Meshnick, S R
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 1995
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162535/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7726490/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.2.325
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