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Conditional RAG-1 Mutants Block the Hairpin Formation Step of V(D)J Recombination

Hairpin formation serves an important regulatory role in V(D)J recombination because it requires synapsis of an appropriate pair of recombination sites. How hairpin formation is regulated and which regions of the RAG proteins perform this step remain unknown. We analyzed two conditional RAG-1 mutant...

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Main Authors: Kale, Sam B., Landree, Mark A., Roth, David B.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2001
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC86598/
https://ncbi.nlm.nih.gov/pubmed/11134334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.2.459-466.2001
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