A RAG-1/RAG-2 Tetramer Supports 12/23-Regulated Synapsis, Cleavage, and Transposition of V(D)J Recombination Signals

Initiation of V(D)J recombination involves the synapsis and cleavage of a 12/23 pair of recombination signal sequences by RAG-1 and RAG-2. Ubiquitous nonspecific DNA-bending factors of the HMG box family, such as HMG-1, are known to assist in these processes. After cleavage, the RAG proteins remain...

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Bibliographic Details
Main Author: Swanson, Patrick C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC134746/
https://ncbi.nlm.nih.gov/pubmed/12391148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.22.7790-7801.2002
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