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Conditional RAG-1 Mutants Block the Hairpin Formation Step of V(D)J Recombination

Hairpin formation serves an important regulatory role in V(D)J recombination because it requires synapsis of an appropriate pair of recombination sites. How hairpin formation is regulated and which regions of the RAG proteins perform this step remain unknown. We analyzed two conditional RAG-1 mutant...

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Bibliografske podrobnosti
Main Authors: Kale, Sam B., Landree, Mark A., Roth, David B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC86598/
https://ncbi.nlm.nih.gov/pubmed/11134334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.2.459-466.2001
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