The c-Myc Transactivation Domain Is a Direct Modulator of Apoptotic versus Proliferative Signals

We have assayed the oncogenic, proliferative, and apoptotic activities of the frequent mutations that occur in the c-myc gene in Burkitt's lymphomas. Some alleles have a modest (50 to 60%) increase in transforming activity; however, the most frequent Burkitt's lymphoma allele (T58I) had an unexpecte...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Chang, David W., Claassen, Gisela F., Hann, Stephen R., Cole, Michael D.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2000
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85798/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10825194/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.12.4309-4319.2000
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