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The c-Myc Transactivation Domain Is a Direct Modulator of Apoptotic versus Proliferative Signals

We have assayed the oncogenic, proliferative, and apoptotic activities of the frequent mutations that occur in the c-myc gene in Burkitt's lymphomas. Some alleles have a modest (50 to 60%) increase in transforming activity; however, the most frequent Burkitt's lymphoma allele (T58I) had an...

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Autori principali: Chang, David W., Claassen, Gisela F., Hann, Stephen R., Cole, Michael D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC85798/
https://ncbi.nlm.nih.gov/pubmed/10825194
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