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Perampanel Reduces Hyperthermia-Induced Seizures in Dravet Syndrome Mouse Model

Treatment options for Dravet syndrome are limited. The aim of this study was to evaluate the antiepileptic effect of the AMPA receptor antagonist perampanel (PER) on a mouse model of Dravet syndrome (Scn1a (E1099X/+)). We report here that the PER (2 mg/kg) treatment inhibited the spontaneous recurre...

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Bibliografische gegevens
Gepubliceerd in:Front Pharmacol
Hoofdauteurs: Ho, Shih-Yin, Lin, Li, Chen, I-Chun, Tsai, Che-Wen, Chang, Fang-Chia, Liou, Horng-Huei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317459/
https://ncbi.nlm.nih.gov/pubmed/34335252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.682767
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