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Perampanel Reduces Hyperthermia-Induced Seizures in Dravet Syndrome Mouse Model

Treatment options for Dravet syndrome are limited. The aim of this study was to evaluate the antiepileptic effect of the AMPA receptor antagonist perampanel (PER) on a mouse model of Dravet syndrome (Scn1a (E1099X/+)). We report here that the PER (2 mg/kg) treatment inhibited the spontaneous recurre...

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Publicat a:Front Pharmacol
Autors principals: Ho, Shih-Yin, Lin, Li, Chen, I-Chun, Tsai, Che-Wen, Chang, Fang-Chia, Liou, Horng-Huei
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317459/
https://ncbi.nlm.nih.gov/pubmed/34335252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.682767
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