Perampanel Reduces Hyperthermia-Induced Seizures in Dravet Syndrome Mouse Model

Treatment options for Dravet syndrome are limited. The aim of this study was to evaluate the antiepileptic effect of the AMPA receptor antagonist perampanel (PER) on a mouse model of Dravet syndrome (Scn1a (E1099X/+)). We report here that the PER (2 mg/kg) treatment inhibited the spontaneous recurre...

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Vydáno v:Front Pharmacol
Hlavní autoři: Ho, Shih-Yin, Lin, Li, Chen, I-Chun, Tsai, Che-Wen, Chang, Fang-Chia, Liou, Horng-Huei
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317459/
https://ncbi.nlm.nih.gov/pubmed/34335252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.682767
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