Perampanel Reduces Hyperthermia-Induced Seizures in Dravet Syndrome Mouse Model

Treatment options for Dravet syndrome are limited. The aim of this study was to evaluate the antiepileptic effect of the AMPA receptor antagonist perampanel (PER) on a mouse model of Dravet syndrome (Scn1a (E1099X/+)). We report here that the PER (2 mg/kg) treatment inhibited the spontaneous recurre...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Ho, Shih-Yin, Lin, Li, Chen, I-Chun, Tsai, Che-Wen, Chang, Fang-Chia, Liou, Horng-Huei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317459/
https://ncbi.nlm.nih.gov/pubmed/34335252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.682767
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