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Perampanel Reduces Hyperthermia-Induced Seizures in Dravet Syndrome Mouse Model
Treatment options for Dravet syndrome are limited. The aim of this study was to evaluate the antiepileptic effect of the AMPA receptor antagonist perampanel (PER) on a mouse model of Dravet syndrome (Scn1a (E1099X/+)). We report here that the PER (2 mg/kg) treatment inhibited the spontaneous recurre...
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| izdano v: | Front Pharmacol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8317459/ https://ncbi.nlm.nih.gov/pubmed/34335252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.682767 |
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