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The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model

Dravet syndrome is an infant-onset epileptic encephalopathy with multiple seizure types that are often refractory to conventional therapies. Treatment with standard benzodiazepines like clobazam, in combination with valproate and stiripentol, provides only modest seizure control. While benzodiazepin...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Hawkins, Nicole A., Lewis, Michael, Hammond, Rebecca S., Doherty, James J., Kearney, Jennifer A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681541/
https://ncbi.nlm.nih.gov/pubmed/29127345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15609-w
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