The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model

Dravet syndrome is an infant-onset epileptic encephalopathy with multiple seizure types that are often refractory to conventional therapies. Treatment with standard benzodiazepines like clobazam, in combination with valproate and stiripentol, provides only modest seizure control. While benzodiazepin...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Hawkins, Nicole A., Lewis, Michael, Hammond, Rebecca S., Doherty, James J., Kearney, Jennifer A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681541/
https://ncbi.nlm.nih.gov/pubmed/29127345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15609-w
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