Distinct states of proinsulin misfolding in MIDY

A precondition for efficient proinsulin export from the endoplasmic reticulum (ER) is that proinsulin meets ER quality control folding requirements, including formation of the Cys(B19)–Cys(A20) “interchain” disulfide bond, facilitating formation of the Cys(B7)–Cys(A7) bridge. The third proinsulin di...

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Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: Haataja, Leena, Arunagiri, Anoop, Hassan, Anis, Regan, Kaitlin, Tsai, Billy, Dhayalan, Balamurugan, Weiss, Michael A., Liu, Ming, Arvan, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316239/
https://ncbi.nlm.nih.gov/pubmed/34245311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-021-03871-1
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