Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion

In heterozygous patients with a diabetic syndrome called mutant INS gene–induced diabetes of youth (MIDY), there is decreased insulin secretion when mutant proinsulin expression prevents wild-type (WT) proinsulin from exiting the endoplasmic reticulum (ER), which is essential for insulin production....

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Detalles Bibliográficos
Publicado en:Diabetes
Main Authors: Cunningham, Corey N., He, Kaiyu, Arunagiri, Anoop, Paton, Adrienne W., Paton, James C., Arvan, Peter, Tsai, Billy
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2017
Assuntos:
Pathophysiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319713/
https://ncbi.nlm.nih.gov/pubmed/28028074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1338
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