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Cells deploy a two-pronged strategy to rectify misfolded proinsulin aggregates
Insulin gene coding sequence mutations are known to cause Mutant INS-gene-induced Diabetes of Youth (MIDY), yet the cellular pathways needed to prevent misfolded proinsulin accumulation remain incompletely understood. Here we report that Akita mutant proinsulin forms detergent-insoluble aggregates t...
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| I publikationen: | Mol Cell |
|---|---|
| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6688957/ https://ncbi.nlm.nih.gov/pubmed/31176671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.05.011 |
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