Proinsulin misfolding is an early event in the progression to type 2 diabetes

Biosynthesis of insulin – critical to metabolic homeostasis – begins with folding of the proinsulin precursor, including formation of three evolutionarily conserved intramolecular disulfide bonds. Remarkably, normal pancreatic islets contain a subset of proinsulin molecules bearing at least one free...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Arunagiri, Anoop, Haataja, Leena, Pottekat, Anita, Pamenan, Fawnnie, Kim, Soohyun, Zeltser, Lori M, Paton, Adrienne W, Paton, James C, Tsai, Billy, Itkin-Ansari, Pamela, Kaufman, Randal J, Liu, Ming, Arvan, Peter
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559786/
https://ncbi.nlm.nih.gov/pubmed/31184302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44532
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