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Proinsulin misfolding is an early event in the progression to type 2 diabetes
Biosynthesis of insulin – critical to metabolic homeostasis – begins with folding of the proinsulin precursor, including formation of three evolutionarily conserved intramolecular disulfide bonds. Remarkably, normal pancreatic islets contain a subset of proinsulin molecules bearing at least one free...
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| Veröffentlicht in: | eLife |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6559786/ https://ncbi.nlm.nih.gov/pubmed/31184302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44532 |
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