Učitavanje...
Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes
The endoplasmic reticulum (ER) is broadly distributed throughout the cytoplasm of pancreatic beta cells, and this is where all proinsulin is initially made. Healthy beta cells can synthesize 6000 proinsulin molecules per second. Ordinarily, nascent proinsulin entering the ER rapidly folds via the fo...
Spremljeno u:
| Izdano u: | Ann N Y Acad Sci |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
|
| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5934315/ https://ncbi.nlm.nih.gov/pubmed/29377149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13531 |
| Oznake: |
Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|