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Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes
The endoplasmic reticulum (ER) is broadly distributed throughout the cytoplasm of pancreatic beta cells, and this is where all proinsulin is initially made. Healthy beta cells can synthesize 6000 proinsulin molecules per second. Ordinarily, nascent proinsulin entering the ER rapidly folds via the fo...
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| Foilsithe in: | Ann N Y Acad Sci |
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| Main Authors: | , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2018
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5934315/ https://ncbi.nlm.nih.gov/pubmed/29377149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13531 |
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