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Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes
The endoplasmic reticulum (ER) is broadly distributed throughout the cytoplasm of pancreatic beta cells, and this is where all proinsulin is initially made. Healthy beta cells can synthesize 6000 proinsulin molecules per second. Ordinarily, nascent proinsulin entering the ER rapidly folds via the fo...
Enregistré dans:
| Publié dans: | Ann N Y Acad Sci |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5934315/ https://ncbi.nlm.nih.gov/pubmed/29377149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13531 |
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