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Proinsulin Disulfide Maturation and Misfolding in the Endoplasmic Reticulum
Upon nonreducing Tris-Tricine-urea-SDS-PAGE, newly synthesized proinsulin from pancreatic islets of normal rodents forms a band fast mobility representing the native disulfide isomer, which is efficiently secreted. In addition at least two slower migrating “isomer 1 and 2” bands are recovered, not d...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527538/ https://ncbi.nlm.nih.gov/pubmed/15705595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C400475200 |
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