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Proinsulin Misfolding and Endoplasmic Reticulum Stress During the Development and Progression of Diabetes(1)
To maintain copious insulin granule stores in the face of ongoing metabolic demand, pancreatic beta cells must produce large quantities of proinsulin, the insulin precursor. Proinsulin biosynthesis can account for up to 30–50% of total cellular protein synthesis of beta cells. This puts pressure on...
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| Publicado no: | Mol Aspects Med |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4404191/ https://ncbi.nlm.nih.gov/pubmed/25579745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mam.2015.01.001 |
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