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Misfolded Proinsulin Affects Bystander Proinsulin in Neonatal Diabetes
It has previously been shown that misfolded mutant Akita proinsulin in the endoplasmic reticulum engages directly in protein complexes either with nonmutant proinsulin or with “hProCpepGFP” (human proinsulin bearing emerald-GFP within the C-peptide), impairing the trafficking of these “bystander” pr...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804216/ https://ncbi.nlm.nih.gov/pubmed/19880509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038042 |
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