Misfolded Proinsulin Affects Bystander Proinsulin in Neonatal Diabetes

It has previously been shown that misfolded mutant Akita proinsulin in the endoplasmic reticulum engages directly in protein complexes either with nonmutant proinsulin or with “hProCpepGFP” (human proinsulin bearing emerald-GFP within the C-peptide), impairing the trafficking of these “bystander” pr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hodish, Israel, Liu, Ming, Rajpal, Gautam, Larkin, Dennis, Holz, Ronald W., Adams, Aaron, Liu, Leanza, Arvan, Peter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Molecular Basis of Cell and Developmental Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804216/
https://ncbi.nlm.nih.gov/pubmed/19880509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038042
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