Misfolded Proinsulin Affects Bystander Proinsulin in Neonatal Diabetes

It has previously been shown that misfolded mutant Akita proinsulin in the endoplasmic reticulum engages directly in protein complexes either with nonmutant proinsulin or with “hProCpepGFP” (human proinsulin bearing emerald-GFP within the C-peptide), impairing the trafficking of these “bystander” pr...

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Main Authors: Hodish, Israel, Liu, Ming, Rajpal, Gautam, Larkin, Dennis, Holz, Ronald W., Adams, Aaron, Liu, Leanza, Arvan, Peter
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
主題:
Molecular Basis of Cell and Developmental Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804216/
https://ncbi.nlm.nih.gov/pubmed/19880509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038042
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