Misfolded Proinsulin Affects Bystander Proinsulin in Neonatal Diabetes

It has previously been shown that misfolded mutant Akita proinsulin in the endoplasmic reticulum engages directly in protein complexes either with nonmutant proinsulin or with “hProCpepGFP” (human proinsulin bearing emerald-GFP within the C-peptide), impairing the trafficking of these “bystander” pr...

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Detalhes bibliográficos
Main Authors: Hodish, Israel, Liu, Ming, Rajpal, Gautam, Larkin, Dennis, Holz, Ronald W., Adams, Aaron, Liu, Leanza, Arvan, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804216/
https://ncbi.nlm.nih.gov/pubmed/19880509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038042
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