Misfolded Proinsulin Affects Bystander Proinsulin in Neonatal Diabetes

It has previously been shown that misfolded mutant Akita proinsulin in the endoplasmic reticulum engages directly in protein complexes either with nonmutant proinsulin or with “hProCpepGFP” (human proinsulin bearing emerald-GFP within the C-peptide), impairing the trafficking of these “bystander” pr...

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Hlavní autoři: Hodish, Israel, Liu, Ming, Rajpal, Gautam, Larkin, Dennis, Holz, Ronald W., Adams, Aaron, Liu, Leanza, Arvan, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Molecular Basis of Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804216/
https://ncbi.nlm.nih.gov/pubmed/19880509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038042
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