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In Vivo Misfolding of Proinsulin Below the Threshold of Frank Diabetes
OBJECTIVE: Endoplasmic reticulum (ER) stress has been described in pancreatic β-cells after onset of diabetes—a situation in which failing β-cells have exhausted available compensatory mechanisms. Herein we have compared two mouse models expressing equally small amounts of transgenic proinsulin in p...
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Diabetes Association
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3142084/ https://ncbi.nlm.nih.gov/pubmed/21677281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1671 |
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