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Proinsulin maturation, misfolding, and proteotoxicity
As a tool to explore proinsulin (PI) trafficking, a human PI cDNA has been constructed with GFP fused within the C peptide. In regulated secretory cells containing appropriate prohormone convertases, the hProCpepGFP construct undergoes endoproteolytic processing to CpepGFP and native human insulin,...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2000385/ https://ncbi.nlm.nih.gov/pubmed/17898179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702697104 |
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