Proinsulin maturation, misfolding, and proteotoxicity

As a tool to explore proinsulin (PI) trafficking, a human PI cDNA has been constructed with GFP fused within the C peptide. In regulated secretory cells containing appropriate prohormone convertases, the hProCpepGFP construct undergoes endoproteolytic processing to CpepGFP and native human insulin,...

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Detaylı Bibliyografya
Asıl Yazarlar: Liu, Ming, Hodish, Israel, Rhodes, Christopher J., Arvan, Peter
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2007
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000385/
https://ncbi.nlm.nih.gov/pubmed/17898179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702697104
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