Cells deploy a two-pronged strategy to rectify misfolded proinsulin aggregates

Insulin gene coding sequence mutations are known to cause Mutant INS-gene-induced Diabetes of Youth (MIDY), yet the cellular pathways needed to prevent misfolded proinsulin accumulation remain incompletely understood. Here we report that Akita mutant proinsulin forms detergent-insoluble aggregates t...

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Udgivet i:Mol Cell
Main Authors: Cunningham, Corey N., Williams, Jeffrey M., Knupp, Jeffrey, Arunagiri, Anoop, Arvan, Peter, Tsai, Billy
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688957/
https://ncbi.nlm.nih.gov/pubmed/31176671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.05.011
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