Distinct states of proinsulin misfolding in MIDY

A precondition for efficient proinsulin export from the endoplasmic reticulum (ER) is that proinsulin meets ER quality control folding requirements, including formation of the Cys(B19)–Cys(A20) “interchain” disulfide bond, facilitating formation of the Cys(B7)–Cys(A7) bridge. The third proinsulin di...

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Bibliografiske detaljer
Udgivet i:Cell Mol Life Sci
Main Authors: Haataja, Leena, Arunagiri, Anoop, Hassan, Anis, Regan, Kaitlin, Tsai, Billy, Dhayalan, Balamurugan, Weiss, Michael A., Liu, Ming, Arvan, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2021
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316239/
https://ncbi.nlm.nih.gov/pubmed/34245311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-021-03871-1
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