Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase using Small Molecule Fragments.

Fragment screening is a powerful drug discovery approach particularly useful for enzymes difficult to inhibit selectively such as the thiol/selenol-dependent thioredoxin reductases (TrxRs), which are essential and druggable in several infectious diseases. Several known inhibitors are reactive electr...

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Publicado no:ACS Infect Dis
Main Authors: Fata, Francesca, Silvestri, Ilaria, Ardini, Matteo, Ippoliti, Rodolfo, Di Leandro, Luana, Demitri, Nicola, Polentarutti, Maurizio, Di Matteo, Adele, Lyu, Haining, Thatcher, Gregory R.J., Petukhov, Pavel A., WiIliams, David L., Angelucci, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273128/
https://ncbi.nlm.nih.gov/pubmed/33950676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00909
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