Ectopic suicide inhibition of thioredoxin glutathione reductase

Selective suicide inhibitors represent a seductively attractive approach for inactivation of therapeutically relevant enzymes since they are generally devoid of off-target toxicity in vivo. While most suicide inhibitors are converted to reactive species at enzyme active sites, theoretically bioactiv...

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Veröffentlicht in:Free Radic Biol Med
Hauptverfasser: Silvestri, Ilaria, Lyu, Haining, Fata, Francesca, Banta, Paul R., Mattei, Benedetta, Ippoliti, Rodolfo, Bellelli, Andrea, Pitari, Giuseppina, Ardini, Matteo, Petukhova, Valentina, Thatcher, Gregory R.J., Petukhov, Pavel A., Williams, David L., Angelucci, Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7583042/
https://ncbi.nlm.nih.gov/pubmed/31870799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.12.019
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