Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry

Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases. However, individual FAD/NAD reductases are difficult to inhibit in a selective manner with off target inhibition reducing usefulness of i...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:ACS Chem Biol
Egile Nagusiak: Silvestri, Ilaria, Lyu, Haining, Fata, Francesca, Boumis, Giovanna, Miele, Adriana E., Ardini, Matteo, Ippoliti, Rodolfo, Bellelli, Andrea, Jadhav, Ajit, Lea, Wendy A., Simeonov, Anton, Cheng, Qing, Arnér, Elias S. J., Thatcher, Gregory R., Petukhov, Pavel A., Williams, David L., Angelucci, Francesco
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905387/
https://ncbi.nlm.nih.gov/pubmed/29800515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00349
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