Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry

Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases. However, individual FAD/NAD reductases are difficult to inhibit in a selective manner with off target inhibition reducing usefulness of i...

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Publicado en:ACS Chem Biol
Main Authors: Silvestri, Ilaria, Lyu, Haining, Fata, Francesca, Boumis, Giovanna, Miele, Adriana E., Ardini, Matteo, Ippoliti, Rodolfo, Bellelli, Andrea, Jadhav, Ajit, Lea, Wendy A., Simeonov, Anton, Cheng, Qing, Arnér, Elias S. J., Thatcher, Gregory R., Petukhov, Pavel A., Williams, David L., Angelucci, Francesco
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905387/
https://ncbi.nlm.nih.gov/pubmed/29800515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00349
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