Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry

Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases. However, individual FAD/NAD reductases are difficult to inhibit in a selective manner with off target inhibition reducing usefulness of i...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Silvestri, Ilaria, Lyu, Haining, Fata, Francesca, Boumis, Giovanna, Miele, Adriana E., Ardini, Matteo, Ippoliti, Rodolfo, Bellelli, Andrea, Jadhav, Ajit, Lea, Wendy A., Simeonov, Anton, Cheng, Qing, Arnér, Elias S. J., Thatcher, Gregory R., Petukhov, Pavel A., Williams, David L., Angelucci, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905387/
https://ncbi.nlm.nih.gov/pubmed/29800515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00349
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados