Inhibition of Schistosoma mansoni Thioredoxin-glutathione Reductase by Auranofin: STRUCTURAL AND KINETIC ASPECTS

Schistosomiasis is a parasitic disease affecting over 200 million people currently treated with one drug, praziquantel. A possible drug target is the seleno-protein thioredoxin-glutathione reductase (TGR), a key enzyme in the pathway of the parasite for detoxification of reactive oxygen species. The...

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Main Authors: Angelucci, Francesco, Sayed, Ahmed A., Williams, David L., Boumis, Giovanna, Brunori, Maurizio, Dimastrogiovanni, Daniela, Miele, Adriana E., Pauly, Frida, Bellelli, Andrea
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Enzyme Catalysis and Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781444/
https://ncbi.nlm.nih.gov/pubmed/19710012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.020701
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