Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

The aberrant aggregation of proteins is a key molecular event in the development and progression of a wide range of neurodegenerative disorders. We have shown previously that squalamine and trodusquemine, two natural products in the aminosterol class, can modulate the aggregation of the amyloid-β pe...

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Vydáno v:Front Neurosci
Hlavní autoři: Limbocker, Ryan, Staats, Roxine, Chia, Sean, Ruggeri, Francesco S., Mannini, Benedetta, Xu, Catherine K., Perni, Michele, Cascella, Roberta, Bigi, Alessandra, Sasser, Liam R., Block, Natalie R., Wright, Aidan K., Kreiser, Ryan P., Custy, Edward T., Meisl, Georg, Errico, Silvia, Habchi, Johnny, Flagmeier, Patrick, Kartanas, Tadas, Hollows, Jared E., Nguyen, Lam T., LeForte, Kathleen, Barbut, Denise, Kumita, Janet R., Cecchi, Cristina, Zasloff, Michael, Knowles, Tuomas P. J., Dobson, Christopher M., Chiti, Fabrizio, Vendruscolo, Michele
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249941/
https://ncbi.nlm.nih.gov/pubmed/34220435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.680026
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