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Glutamine Inhibition Reduces Iatrogenic Laryngotracheal Stenosis

OBJECTIVE/HYPOTHESIS: Glutamine inhibition has been demonstrated an antifibrotic effect in iatrogenic laryngotracheal stenosis (iLTS) scar fibroblasts in vitro. We hypothesize that broadly active glutamine antagonist, DON will reduce collagen formation and fibrosis-associated gene expression in iLTS...

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Dades bibliogràfiques
Publicat a:Laryngoscope
Autors principals: Tsai, Hsiu-Wen, Lina, Ioan, Motz, Kevin M, Chung, Liam, Ding, Dacheng, Murphy, Michael K., Feeley, Michael, Elisseeff, Jennifer H., Hillel, Alexander T.
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205976/
https://ncbi.nlm.nih.gov/pubmed/33433011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.29385
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