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Glutamine Inhibition Reduces Iatrogenic Laryngotracheal Stenosis

OBJECTIVE/HYPOTHESIS: Glutamine inhibition has been demonstrated an antifibrotic effect in iatrogenic laryngotracheal stenosis (iLTS) scar fibroblasts in vitro. We hypothesize that broadly active glutamine antagonist, DON will reduce collagen formation and fibrosis-associated gene expression in iLTS...

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Detalhes bibliográficos
Publicado no:Laryngoscope
Main Authors: Tsai, Hsiu-Wen, Lina, Ioan, Motz, Kevin M, Chung, Liam, Ding, Dacheng, Murphy, Michael K., Feeley, Michael, Elisseeff, Jennifer H., Hillel, Alexander T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205976/
https://ncbi.nlm.nih.gov/pubmed/33433011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.29385
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