Glutamine Inhibition Reduces Iatrogenic Laryngotracheal Stenosis

OBJECTIVE/HYPOTHESIS: Glutamine inhibition has been demonstrated an antifibrotic effect in iatrogenic laryngotracheal stenosis (iLTS) scar fibroblasts in vitro. We hypothesize that broadly active glutamine antagonist, DON will reduce collagen formation and fibrosis-associated gene expression in iLTS...

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Détails bibliographiques
Publié dans:Laryngoscope
Auteurs principaux: Tsai, Hsiu-Wen, Lina, Ioan, Motz, Kevin M, Chung, Liam, Ding, Dacheng, Murphy, Michael K., Feeley, Michael, Elisseeff, Jennifer H., Hillel, Alexander T.
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205976/
https://ncbi.nlm.nih.gov/pubmed/33433011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.29385
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