Inhibition of Glutaminase to Reverse Fibrosis in Iatrogenic Laryngotracheal Stenosis

OBJECTIVES/HYPOTHESIS: Glutamine metabolism is a critical energy source for iatrogenic laryngotracheal stenosis (iLTS) scar fibroblasts, and glutaminase (GLS) is an essential enzyme converting glutamine to glutamate. We hypothesize that the GLS-specific inhibitor BPTES will block glutaminolysis and...

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Bibliografiska uppgifter
I publikationen:Laryngoscope
Huvudupphovsmän: Tsai, Hsiu-Wen, Motz, Kevin M., Ding, Dacheng, Lina, Ioan, Murphy, Michael K., Benner, Dimitri, Feeley, Michael, Hooper, Jody, Hillel, Alexander T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335682/
https://ncbi.nlm.nih.gov/pubmed/31904876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.28493
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