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Inhibition of Glutaminase to Reverse Fibrosis in Iatrogenic Laryngotracheal Stenosis
OBJECTIVES/HYPOTHESIS: Glutamine metabolism is a critical energy source for iatrogenic laryngotracheal stenosis (iLTS) scar fibroblasts, and glutaminase (GLS) is an essential enzyme converting glutamine to glutamate. We hypothesize that the GLS-specific inhibitor BPTES will block glutaminolysis and...
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| Publicat a: | Laryngoscope |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7335682/ https://ncbi.nlm.nih.gov/pubmed/31904876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.28493 |
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