Targeting Metabolic Abnormalities to Reverse Fibrosis in Iatrogenic Laryngotracheal Stenosis

OBJECTIVE: Management of laryngotracheal stenosis (LTS) remains primarily surgical, with a critical need to identify targets for adjuvant therapy. Laryngotracheal stenosis scar fibroblasts exhibit a profibrotic phenotype with distinct metabolic shifts, including an increased glycolysis/oxidative pho...

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Gepubliceerd in:Laryngoscope
Hoofdauteurs: Murphy, Michael K., Motz, Kevin M, Ding, Dacheng, Yin, Linda, Duvvuri, Madhavi, Feeley, Michael, Hillel, Alexander T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771827/
https://ncbi.nlm.nih.gov/pubmed/28940431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.26893
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