Structural basis of nucleosome-dependent cGAS inhibition()

Cyclic GMP-AMP synthase (cGAS) recognizes cytosolic foreign or damaged DNA to activate the innate immune response to infection, inflammatory diseases, and cancer. In contrast, cGAS reactivity against self-DNA in the nucleus is suppressed by chromatin tethering. We report a 3.3-angstrom-resolution cr...

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Bibliographic Details
Published in:Science
Main Authors: Boyer, Joshua A., Spangler, Cathy J., Strauss, Joshua D., Cesmat, Andrew P., Liu, Pengda, McGinty, Robert K., Zhang, Qi
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8189757/
https://ncbi.nlm.nih.gov/pubmed/32913000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abd0609
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