Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity

cGAS/STING signaling plays an essential role in sensing cytosolic DNA. cGAS activity is regulated by posttranslational modifications and binding partners. cGAS interactome largely includes mammalian or viral proteins. Whether and how bacterial proteins bind cGAS to modulate innate immunity remain el...

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Udgivet i:iScience
Main Authors: Zhang, Yanqiong, Ma, Zhe, Wang, Ying, Boyer, Joshua, Ni, Guoxin, Cheng, Liang, Su, Siyuan, Zhang, Zhigang, Zhu, Zhichuan, Qian, Jiayi, Su, Lishan, Zhang, Qi, Damania, Blossom, Liu, Pengda
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476851/
https://ncbi.nlm.nih.gov/pubmed/32861998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101463
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