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Structural basis for nucleosome-mediated inhibition of cGAS activity
Activation of cyclic GMP-AMP synthase (cGAS) through sensing cytosolic double stranded DNA (dsDNA) plays a pivotal role in innate immunity against exogenous infection as well as cellular regulation under stress. Aberrant activation of cGAS induced by self-DNA is related to autoimmune diseases. cGAS...
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| Yayımlandı: | Cell Res |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Springer Singapore
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7784699/ https://ncbi.nlm.nih.gov/pubmed/33051594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-020-00422-4 |
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