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Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression

DNA transfection is often the bottleneck of research and gene therapy practices. To explore the mechanism regulating transgene expression, we investigated the role of the cGAS-STING signaling pathway, which induces type-I interferons in response to DNA. We confirmed that deletion of cGAS enhances tr...

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הוצא לאור ב:	iScience
Main Authors:	Fu, Yajuan, Fang, Yijun, Lin, Zhang, Yang, Lei, Zheng, Liqun, Hu, Hao, Yu, Tingting, Huang, Baoting, Chen, Suxing, Wang, Hanze, Xu, Shan, Bao, Wei, Chen, Qi, Sun, Lijun
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2020
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7155207/ https://ncbi.nlm.nih.gov/pubmed/32283527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101026
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Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression

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