Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response

Cyclic GMP-AMP synthase (cGAS), serving as a primary sensor of intracellular DNA, is essential to initiate anti-microbial innate immunity. Inappropriate activation of cGAS by self-DNA promotes severe autoinflammatory diseases such as Aicardi–Goutières syndrome (AGS); thus, inhibition of cGAS may pro...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Chu, Lei, Li, Chenhui, Li, Yongxing, Yu, Qiuya, Yu, Huansha, Li, Chunhui, Meng, Wei, Zhu, Juanjuan, Wang, Quanyi, Wang, Chen, Cui, Shufang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100446/
https://ncbi.nlm.nih.gov/pubmed/33968056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.655637
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