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Allosteric coupling between Mn(2+) and dsDNA controls the catalytic efficiency and fidelity of cGAS
Cyclic-G/AMP (cGAMP) synthase (cGAS) triggers host innate immune responses against cytosolic double-stranded (ds)DNA arising from genotoxic stress and pathogen invasion. The canonical activation mechanism of cGAS entails dsDNA-binding and dimerization. Here, we report an unexpected activation mechan...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7192592/ https://ncbi.nlm.nih.gov/pubmed/32170294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa084 |
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