Allosteric coupling between Mn(2+) and dsDNA controls the catalytic efficiency and fidelity of cGAS

Cyclic-G/AMP (cGAMP) synthase (cGAS) triggers host innate immune responses against cytosolic double-stranded (ds)DNA arising from genotoxic stress and pathogen invasion. The canonical activation mechanism of cGAS entails dsDNA-binding and dimerization. Here, we report an unexpected activation mechan...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Hooy, Richard M, Massaccesi, Guido, Rousseau, Kimberly E, Chattergoon, Michael A, Sohn, Jungsan
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Nucleic Acid Enzymes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192592/
https://ncbi.nlm.nih.gov/pubmed/32170294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa084
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