Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus known to cause epidemics resulting in predominantly symptomatic infections, which in rare cases cause long term debilitating arthritis and arthralgia. Significant progress has been made in understanding the roles of canonical RNA sensing pathw...

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Udgivet i:PLoS Pathog
Main Authors: Webb, L. G., Veloz, J., Pintado-Silva, J., Zhu, T., Rangel, M. V., Mutetwa, T., Zhang, L., Bernal-Rubio, D., Figueroa, D., Carrau, L., Fenutria, R., Potla, U., Reid, St. P., Yount, J. S., Stapleford, K. A., Aguirre, S., Fernandez-Sesma, A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591055/
https://ncbi.nlm.nih.gov/pubmed/33057424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008999
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