Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression

DNA transfection is often the bottleneck of research and gene therapy practices. To explore the mechanism regulating transgene expression, we investigated the role of the cGAS-STING signaling pathway, which induces type-I interferons in response to DNA. We confirmed that deletion of cGAS enhances tr...

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Gepubliceerd in:iScience
Hoofdauteurs: Fu, Yajuan, Fang, Yijun, Lin, Zhang, Yang, Lei, Zheng, Liqun, Hu, Hao, Yu, Tingting, Huang, Baoting, Chen, Suxing, Wang, Hanze, Xu, Shan, Bao, Wei, Chen, Qi, Sun, Lijun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7155207/
https://ncbi.nlm.nih.gov/pubmed/32283527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101026
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