Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression

DNA transfection is often the bottleneck of research and gene therapy practices. To explore the mechanism regulating transgene expression, we investigated the role of the cGAS-STING signaling pathway, which induces type-I interferons in response to DNA. We confirmed that deletion of cGAS enhances tr...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Fu, Yajuan, Fang, Yijun, Lin, Zhang, Yang, Lei, Zheng, Liqun, Hu, Hao, Yu, Tingting, Huang, Baoting, Chen, Suxing, Wang, Hanze, Xu, Shan, Bao, Wei, Chen, Qi, Sun, Lijun
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7155207/
https://ncbi.nlm.nih.gov/pubmed/32283527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101026
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