Structural basis for the inhibition of cGAS by nucleosomes

The cyclic GMP-AMP synthase (cGAS) senses invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy and apoptosis. Organization of host DNA into nucleosomes was proposed to limit cGAS autoinduction, but the underlying mechanism was unknown. Here, we report the structural basis for...

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Pubblicato in:Science
Autori principali: Kujirai, Tomoya, Zierhut, Christian, Takizawa, Yoshimasa, Kim, Ryan, Negishi, Lumi, Uruma, Nobuki, Hirai, Seiya, Funabiki, Hironori, Kurumizaka, Hitoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584773/
https://ncbi.nlm.nih.gov/pubmed/32912999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abd0237
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