Structural basis for the inhibition of cGAS by nucleosomes

The cyclic GMP-AMP synthase (cGAS) senses invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy and apoptosis. Organization of host DNA into nucleosomes was proposed to limit cGAS autoinduction, but the underlying mechanism was unknown. Here, we report the structural basis for...

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Библиографические подробности
Опубликовано в: :Science
Главные авторы: Kujirai, Tomoya, Zierhut, Christian, Takizawa, Yoshimasa, Kim, Ryan, Negishi, Lumi, Uruma, Nobuki, Hirai, Seiya, Funabiki, Hironori, Kurumizaka, Hitoshi
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584773/
https://ncbi.nlm.nih.gov/pubmed/32912999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abd0237
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