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Structural basis for the inhibition of cGAS by nucleosomes
The cyclic GMP-AMP synthase (cGAS) senses invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy and apoptosis. Organization of host DNA into nucleosomes was proposed to limit cGAS autoinduction, but the underlying mechanism was unknown. Here, we report the structural basis for...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7584773/ https://ncbi.nlm.nih.gov/pubmed/32912999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abd0237 |
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