Structural basis for the inhibition of cGAS by nucleosomes

The cyclic GMP-AMP synthase (cGAS) senses invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy and apoptosis. Organization of host DNA into nucleosomes was proposed to limit cGAS autoinduction, but the underlying mechanism was unknown. Here, we report the structural basis for...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Science
Asıl Yazarlar: Kujirai, Tomoya, Zierhut, Christian, Takizawa, Yoshimasa, Kim, Ryan, Negishi, Lumi, Uruma, Nobuki, Hirai, Seiya, Funabiki, Hironori, Kurumizaka, Hitoshi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584773/
https://ncbi.nlm.nih.gov/pubmed/32912999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abd0237
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller