Structural basis for the inhibition of cGAS by nucleosomes

The cyclic GMP-AMP synthase (cGAS) senses invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy and apoptosis. Organization of host DNA into nucleosomes was proposed to limit cGAS autoinduction, but the underlying mechanism was unknown. Here, we report the structural basis for...

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Bibliografski detalji
Izdano u:Science
Glavni autori: Kujirai, Tomoya, Zierhut, Christian, Takizawa, Yoshimasa, Kim, Ryan, Negishi, Lumi, Uruma, Nobuki, Hirai, Seiya, Funabiki, Hironori, Kurumizaka, Hitoshi
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584773/
https://ncbi.nlm.nih.gov/pubmed/32912999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abd0237
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