Structural basis for the inhibition of cGAS by nucleosomes

The cyclic GMP-AMP synthase (cGAS) senses invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy and apoptosis. Organization of host DNA into nucleosomes was proposed to limit cGAS autoinduction, but the underlying mechanism was unknown. Here, we report the structural basis for...

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Bibliografiska uppgifter
I publikationen:Science
Huvudupphovsmän: Kujirai, Tomoya, Zierhut, Christian, Takizawa, Yoshimasa, Kim, Ryan, Negishi, Lumi, Uruma, Nobuki, Hirai, Seiya, Funabiki, Hironori, Kurumizaka, Hitoshi
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584773/
https://ncbi.nlm.nih.gov/pubmed/32912999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abd0237
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