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Structural basis of nucleosome-dependent cGAS inhibition()
Cyclic GMP-AMP synthase (cGAS) recognizes cytosolic foreign or damaged DNA to activate the innate immune response to infection, inflammatory diseases, and cancer. In contrast, cGAS reactivity against self-DNA in the nucleus is suppressed by chromatin tethering. We report a 3.3-angstrom-resolution cr...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8189757/ https://ncbi.nlm.nih.gov/pubmed/32913000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abd0609 |
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